This study was aimed to examine the impact of different levels of dietary nucleotides (Vannagen) on serum
biochemical and blood parameters of Persian sturgeon (Acipenser persicus). Fish (42.37± 2.12 g and 23.67±
0.61 cm) were divided into four treatments with different levels of dietary nucleotides (0, 0.25, 0.35 and 0.5
percent of diet). There were three replicates with a density of 12 fish per tank. After 10 weeks of feeding,
serum biochemical and blood parameters were measured. Among the measured factors, blood glucose,
triglycerides, cholesterol, erythrocyte and heterophil showed significant differences between the groups fed
with nucleotides and the control group (P ≤ 0.05). By increasing the nucleotide levels, the mean heterophil
and serum glucose showed significant increase and decrease, respectively. The highest and lowest values of
cholesterol and triglyceride were found in groups fed with 0.25% and 0.35% nucleotides, respectively. The
other measured factors had no significant difference (P≤0.05). Therefore, it could be said that with regard to
the limited capacity of cells to synthesize nucleotides, external preparing of nucleotides could result in the
production of needed nucleotides and an increase of its production speed, especially during stress. Such
preparation can also improve fish physiology and health status.