This study was conducted to measure the accumulation of heavy metals (Co and Ni) in the edible tissues of common carp (Cyprinus carpio) and comparison with international standards of FAO and FDA. Samples were caught from the West, Centre and East part of Anzali Wetland in autumn of 2012. Accumulations of heavy metals were measured by flame atomic absorption spectrophotometer. The level of nickel in the West, Centre and East part of Anzali wetland was in permissible range. Cobalt was not observed in carp fish of western wetland. But, concentration of cobalt was not showed any significant differences compared with standard levels of FDA and FAO in East and Centre parts of wetland (p>0.05). The results showed that there were not significant differences of the cobalt and nickel in the tissues of carp among stations (p>0.05). According to the results, carp which caught from Western, Central and Eastern part of Anzali Wetland are suitable for human consumption.