This study was conducted to compare the effect of two anesthetizers Topped lavender essential oil (Lavandula angustifolia) and clove oil on some hematological and serum biochemical parameters in common carp (Cyprinus carpio) juveniles. Common carp juveniles exposed to three treatments including optimum concentration of Topped lavender essential oil (170 mg l^-1), clove oil (35 mg l^-1) and control and hematological, serum biochemical and stress parameters were determined at different times including 0, 3 and 24 h after anesthetizing. The results showed the effect of treatment (anesthetizing agent) on all hematological parameters, the effect of time on WBC, Hb, MCH and MCHC, the interaction effect of treatment and time on Hct and RBC and the effect of treatment, time and the interaction effect of them on all serum biochemical parameters were significant (p<0.05). Over the studied period after anesthetizing, RBC didn’t show significant difference between Topped lavender and control (p>0.05), but in clove oil at the start of anesthetizing time (0) was significantly higher than other sampling times (p<0.05). WBC showed significant decrease compare to other treatments in all sampling times (p<0.05). Over the studied period after anesthetizing, Hb decreased in the control group and increased in Topped lavender and clove oil treatments (p<0.05), Hct also showed significant increase in the control group (p<0.05) and didn’t significant difference in other treatments (p>0.05). In all times, the lowest amount of glucose was observed in Topped lavender treatment; in Topped lavender and clove oil treatment, after increase in 3 h after anesthetizing, showed decrease in 24 h (p<0.05). The amount of Cortisol didn’t have significant difference between the control and Clove oil groups (p>0.05). In all the studied times, higher level of AST in the control, ALT in the control and clove oil, ALP in clove oil and the lower LDH in Topped lavender groups were observed (p<0.05). Overall, although the effect of Topped lavender essential oil on determined parameters showed some difference with clove oil, but Topped lavender essential oil can introduce as native anesthetizing replacement agent for aquaculture.