This study was carried out to comparison and survey on metazoan parasites of Otolithes ruber in coastal waters of Persian Gulf and Sea of Oman. Totally 318 fish specimens were seasonally caught by gill net, bottom trawl and hook in Khozestan, Hormozgan and Sistan and Baluchestan Provinces from summer 2013 to spring 2014. Specimens immediately were frozen and transferred to laboratory and after measuring fish weight and length, parasitological survey conducted on external and internal organs. Totally, 20 different parasites species were observed from O. ruber in mentioned areas that some of them occurred in all three regions and the others were only in one or two areas. The results of this study showed that monogeneans and digeneans had the highest occurrence in three regions while other groups were less abundant in each area. The results of statistical analyses showed significant differences among parasites abundance in different seasons. As well as a significant differences were found between male and female and parasites abundance of Digenea in Khozestan, Monogenea and Cestoda in Hormozgan and Nematoda in Sistan and Baluchesta Provinces. The prevalence of parasites depends on environmental conditions and presence of intermediate hosts that these factors are likely to be different in the three regions.