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:: Volume 26, Issue 2 (7-2017) ::
isfj 2017, 26(2): 37-46 Back to browse issues page
Studing the effect of aqueous extract of the Persian Gulf carpet anemone (Stichodactyla haddoni) on breast cancer cell line in vitro
Z Moghadasi , Shahla Jamili , Delavar Shahbazzadeh , Nariman Mosaffa , Kamran Pooshang Bagheri
Associate Professor Iranian Fisheries Science Research Institute, Agricultural Research, Education and Extension Organization
Abstract:   (653 Views)

Numerous proteins, peptides, and chemical agents in the venom of venomous marine animals are potentially useful biologically active molecules with pharmacological properties. The main goal of this research was to study the cytotoxic effects isolated crude venom from the Persian Gulf sea anemone, Stichodactyla haddoni against Breast, and Human embryonic kidney cell lines in vitro through using MTT assay. Samples of S. haddoni were collected from coastal waters of Lark island Persian Gulf the south of Iran. The extraction of Aqueous from tentacle was performed. The cell line was cultured in complete tissue culture medium. These cells were exposing in presence of different Serial dilution 100 to 0.78 μg of venom extract in duration time 24 hour. Analysis of statistical for cytotoxic activity of crude venom on cell lines this study showed that activity was similar together in almost all doses(Pvalue <0. 05). IC50 of crude venom against breast, and normal cell lines was observed at 4.13, 117.8µg respectively. With increasing extract concentration, death of cells on cells increased.The extraction induced more lethality on breast cell line than normal cell lines. Therefore, crude venom S.haddoni can be considered as a strong preventive grow agent against cancer cell lines especially breast cancer and with low or without toxicity on human normal cells

Keywords: Stichodactyla haddoni, Crude extract, Cytotoxic activity
Full-Text [PDF 811 kb]   (192 Downloads)    
Type of Study: Research | Subject: فيزيولوژي آبزيان
Received: 2016/10/30 | Accepted: 2017/07/2 | Published: 2017/07/2
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DOI: 10.22092/ISFJ.2017.113482


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Moghadasi Z, jamili S, Shahbazzadeh D, Mosaffa N, Pooshang Bagheri K. Studing the effect of aqueous extract of the Persian Gulf carpet anemone (Stichodactyla haddoni) on breast cancer cell line in vitro. isfj. 2017; 26 (2) :37-46
URL: http://isfj.ir/article-1-1664-en.html
Volume 26, Issue 2 (7-2017) Back to browse issues page

با کسب مجوز از دفتر کمیسیون بررسی نشریات علمی وزارت علوم، تحقیات و فنآوری مجله علمی شیلات بصورت آنلاین می باشد و تعداد محدودی هم به چاپ می رساند. شماره شاپای جدید آن ISSN:2322-5998 است

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