TThe objectives of the present study were assess the concentrations of heavy metals (Cd, Zn, Ni, and Cu) in the muscle and liver of Longtail tuna (Thunnus tonggol) and Abu mullet (Liza abu) and to evaluate human health risks associated with their consumption Fish samples were obtained from a fish market in the Bandar Abbas city in the spring 2015. The concentrations of. heavy metals were determined using atomic absorption spectroscopy. The concentrations of copper in the muscles of Longtail tuna and Abu mullet were lower than the international standard limits, whereas the concentrations of cadmium in the muscles of Longtail tuna and Abu mullet were higher than the international standard limits of WHO, NHMRC and UKMAFF. The concentration of zinc in the muscle of Longtail tuna was higher than the international standard limits of WHO. Estimation of Target Hazard Quotient (THQ) and Hazard Index (HI) for children and adults by consumption of the muscles of Longtail tuna and Abu mullet were lower than 1. Estimation of THQ and HI for children and adults by consumption of the liver of Longtail tuna and Abu mullet were higher than 1 for cadmium and copper. Therefore, it can be concluded that there is no human health risk associated with the consumption of the muscle of Longtail tuna and Abu mullet whereas consumption of their livers is not recommended more than once a week.