The present study was conducted to evaluate the effects of dietary Artemisia annua extract on the hematological and blood serum indexes of common carp (Cyprinus carpio). Fish with average initial weight (90.32± 1.12) were fed diets supplemented with graded levels 0, 0.5, 1 and 1.5 % of extract (T1, T2, T3 and T4) for 60 days. At the end of this period, The results showed that growth rate increased significantly (P<0.05) in fish fed diet containing plant extract in T3 (143.70± 10.62 g) compared with the control (130.63± 5.99 g). Results indicated that RBC, Hb and MCHC were higher in fish fed diets containing A. annua compared with the control. WBC, PCV and MCH had no significant change (P>0.05) in experiment groups compared with the control. Serum biochemical parameters showed that glucose levels were significantly increased in extract fed treatments. There was no significant difference in albumin levels between experimental treatments. The results of liver enzymes showed that fish fed diets had no significant difference (P>0.05) in activity of alanine transaminase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) compared with control. The addition of A. annua extract in the diet of common carp compared to control can be an acceptable effect on fish health status, but does not affect the liver enzymes.